Nanomedicine Vol. 16 No. 9 | Research Article

Efficacy, biocompatibility and degradability of carbon nanoparticles for photothermal therapy of lung cancer

Summary

In this Research Article, an international team of researchers affiliated with the University of Torino (Italy), the Karolinska Institutet (Stockholm, Sweden), the National Institute of Metrological Research (Torino, Italy), the Joint Research Centre (Ispra, Italy), the Royal College of Surgeons in Ireland (Dublin, Ireland) and the Polytechnic of Torino (Italy), sought to investigate near infrared-induced phototoxicity toward lung cancer cells, and the biodegradability and effect on immune cells of glucose-derived carbon nanoparticles (CNPs).

Near infrared-activated CNPs elicited rapid cell death, characterized by the elevation of heat shock proteins and the induction of DNA damage. CNPs were found to be noncytotoxic toward primary human macrophages and were susceptible to biodegradation when cocultured with human neutrophils.

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