Nanomedicine Vol. 16 No. 2 | Research Article

Enhanced intraperitoneal delivery of charged, aerosolized curcumin nanoparticles by electrostatic precipitation

Summary

In this study, researchers created cationic and anionic nanoparticles, and studied their tissue uptake in an established ex vivo model of the human peritoneal space after delivery as pressurized intraperitoneal aerosol chemotherapy (PIPAC) versus electrostatic precipitation PIPAC (ePIPAC), in order to test their hypothesis that intraperitoneal delivery of nanoparticles as pressurized aerosols could be further optimized by loading these nanoparticles as either positively or negatively charged.

The study results provide the first evidence that a combination of ePIPAC with positively charged nanoparticles has superior pharmacological properties for intraperitoneal drug delivery.

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