Nanomedicine Vol. 16 No. 10 | Research Article

Genetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field

Summary

In this Research Article, investigators affiliated with Yonsei University (Seoul, Republic of Korea) and the Korea Research Institute of Bioscience & Biotechnology (Daejeon, Republic of Korea) sought to confirm the biological effects of manganese ferrite magnetic nanoparticles (MFMNPs) and an external magnetic field on glioblastoma cells.

LRP6 and TCF7 mRNA levels involved in the Wnt/β-catenin signaling pathway were elevated by the influence of MFMNPs and the external magnetic field. MFMNPs and the external magnetic field also accelerated tumor growth by approximately 7 days and decreased survival rates in animal experiments.

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