Nanomedicine Vol. 16 No. 1 | Research Article

Improved therapeutic antibody delivery to xenograft tumors using cavitation nucleated by gas-entrapping nanoparticles

Summary

In this article, researchers present the first quantitative analysis of delivery of a therapeutic antibody (cetuximab) to solid tumors outside of the brain with ultrasound-mediated cavitation. Delivery of cetuximab is examined in a bilateral xenograft tumor model in mice, and delivery achieved with cavitation seeded with either conventional SonoVue (SV, Bracco) microbubbles or with gas-stabilizing cup-shaped solid SonoTran Particles is compared with delivery achieved after passive accumulation alone. This study provides evidence in support of further research of this noninvasive technique to increase site-specific delivery of this macromolecular drug.

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