Tissue distribution and cellular localization of gold nanocarriers with bound oligonucleotides
In this Research Article, investigators affiliated with The Open University (Milton Keynes, UK), Koç University School of Medicine (Istanbul, Turkey) and the University of Sheffield (UK), aimed to determine how the addition of a DNA oligonucleotide cargo to 3-nm gold glyconanoparticles would affect tissue distribution of the nanoparticles.
The team observed that addition of DNA cargo to the nanocarriers prevented localization in the kidney, but increased localization in liver hepatocytes and splenic macrophages. There was no significant change in heart, lung or brain. DNA increases the size and adds a strong negative charge to the nanocarriers, which radically affects tissue distribution.View the full article Go to Journal Content page