Nanoparticle delivery platform silences genes and fights cancer in mice

Nanoparticle delivery platform for siRNA to tumors

A novel nanoplatform has been developed that acts as a nanoparticle-based vehicle for the delivery of siRNAs to mRNAs, which silences cancer promoting genes in mice. This slows the growth rate of breast cancer tumors and increases the longevity of the mice.   The nanoparticle delivery platforms are made up of porous metal-organic nanoparticles coated in a platelet membrane layer and loaded with synthetic siRNAs. The delivery platforms could aid in cancer therapeutics by broadening the use of targeted acid-based therapies. The nanoparticle delivery platforms could also be used as vector to introduce modified genetic material into host cells for...

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